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目的探讨肺腺癌组织中EGFRvⅢ蛋白表达与EGFR基因突变之间的关系。方法以免疫组化及基因测序方法检测114例肺腺癌肿瘤组织的EGFRvⅢ蛋白表达及EGFR基因的突变。结果 114例中EGFRvⅢ蛋白检出率为30.7%(35/114);EGFR基因突变检出率为47.4%(54/114),主要发生在19、21号外显子。结论 EGFRvⅢ蛋白表达与EGFR基因突变呈正相关,EGFRvⅢ蛋白检测也许可以作为指导肺腺癌患者用药的一种新方法。
Objective To investigate the relationship between EGFRv Ⅲ protein expression and EGFR gene mutation in lung adenocarcinoma. Methods Immunohistochemistry and sequencing were used to detect EGFRvIII protein expression and EGFR gene mutation in 114 lung adenocarcinoma tissues. Results The detection rate of EGFRv Ⅲ protein was 30.7% (35/114) in 114 cases. The positive rate of EGFR gene mutation was 47.4% (54/114), mainly in exons 19 and 21. Conclusion EGFRv Ⅲ protein expression is positively correlated with EGFR gene mutation. The detection of EGFRv Ⅲ protein may be a new method to guide the use of drugs in patients with lung adenocarcinoma.