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检测了95例各期血吸虫病患者血浆纤维连接素(FN),水平,并对22例晚期血吸虫病(晚血)患者脾切除两周后的血浆 FN 水平进行对照观察,同时测定了17例急性血吸虫病(急血)患者外周血单核细胞体外诱生白细胞介素1(IL—1)的水平。急血患者血浆 FN 浓度显著升高并与 IL—1诱生水平明显呈正相关;慢性血吸虫病(慢血)患者血浆 FN 水平正常;晚血组的血浆 FN 浓度明显降低,脾切除后两周血浆 FN 水平显著升高,但仍然明显低于正常水平。提示急血和晚血患者的单核巨噬细胞系统功能分别被激活和受到损害,急血患者血浆 FN 水平的变化可能与 IL—1有关。
The levels of plasma fibronectin (FN) were measured in 95 patients with schistosomiasis stage. The levels of plasma FN in 22 patients with advanced schistosomiasis (late blood) after 2 weeks of splenectomy were measured. Seventeen patients with acute schistosomiasis The level of interleukin-1 (IL-1) induced by peripheral blood mononuclear cells in patients with schistosomiasis (acute blood). The plasma FN levels in patients with acute hemorrhage were significantly increased and positively correlated with IL-1 induced levels. The levels of plasma FN in patients with chronic schistosomiasis (normotensive) were normal. The levels of plasma FN in late blood were significantly decreased, FN levels increased significantly, but still significantly lower than normal levels. It is suggested that the function of monocyte-macrophage system in patients with acute and late blood is activated and impaired respectively. The change of plasma FN level in patients with acute blood may be related to IL-1.