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目的 总结皮肌炎与多发性肌炎的临床表现和治疗经验。方法 1990 ~2004年湖北省荆门市第一人民医院分析73例皮肌炎与多发性肌炎患者的临床和实验室资料。结果 皮肌炎发病年龄11 ~66 ( 42. 56±14 69)岁。病程(16 .49±22. 36)个月, 9 7%合并肿瘤,无肌病性皮肌炎占皮肌炎4 .9%。多发性肌炎发病年龄15~68(43. 09±14 .63)岁,病程(25 .94±31 .78)个月, 6 5%合并肿瘤。皮肌炎多发性肌炎合并肺纤维化差异无显著性。结论 发病年龄大,并发肿瘤或肺纤维化者预后差,早期给予激素和免疫抑制剂治疗是改善预后的关键。
Objective To summarize the clinical manifestation and treatment experience of dermatomyositis and polymyositis. Methods The clinical and laboratory data of 73 patients with dermatomyositis and polymyositis were analyzed from 1990 to 2004 in the First People’s Hospital of Jingmen, Hubei Province. Results The incidence of dermatomyositis was between 11 and 66 (42. 56 ± 14 69) years old. Course of disease (16.49 ± 22.36) months, 97% with tumor, myopathy-free dermatomyositis accounted for 4. .9%. The age of onset of polymyositis was 15-68 (43.09 ± 14.63) years, duration of disease (25.94 ± 31.78) months, 65% with tumor. Dermatomyositis polymyositis with pulmonary fibrosis no significant difference. Conclusion The age of onset, complicated with tumor or pulmonary fibrosis prognosis is poor, early hormone and immunosuppressive therapy is the key to improving prognosis.