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氯乙亚硝脲(BCNU Carmustine),又名卡氮芥,已在白血病、肺癌和脑瘤等多种肿瘤的治疗中广泛应用。本品在脑瘤治疗给药途径的研究中,曾经历了由静脉到动脉输注的改进过程,现已被多数的临床所采用。本文报告将本品改为脑内直接注射给药的实验研究。 8～10周龄BALB/c纯系小鼠,雄雌各半。随机分为8只对照、20只常量和9只倍量用药3个组。BCNU用量按人的大剂量一次给药7.5mg/kg推算,小鼠为125μg/只,此为常量组;倍量组为250μg/只;对照组以36μ1生理盐
BCNU Carmustine, also known as Carbox mustard, has been used extensively in the treatment of leukemias, lung cancers and brain tumors. This product in the brain tumor treatment route of study, has experienced from vein to artery infusion of improved process, has now been the majority of clinical use. This article reports the product into the brain by direct injection of experimental study. 8 to 10 weeks old BALB / c mice, half male and female. Randomly divided into 8 control, 20 constant and 9 times the amount of medication 3 groups. BCNU dosage according to the human large dose of 7.5mg / kg administration, the mouse was 125μg / only, this is a constant group; times the amount of 250μg / group; control group with 36μ1 physiological salt