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目的探讨感觉神经肽在鼻后滴漏综合征(PNDs)性咳嗽患者中的作用。方法收集2004年3月至2005年9月就诊于暨南大学附属第一医院呼吸内科的PNDs性咳嗽患者23例和PNDs患者16例,采用放射免疫法测定诱导痰上清液P物质(SP)、降钙素基因相关肽(CGRP)的质量浓度,另有8名健康成人为对照组。结果PNDs性咳嗽组SP(345.14±72.58)mg/L、CGRP(573.78±210.96)mg/L,与健康对照组[SP(168.14±56.97)mg/L、CGRP(227.69±70.84)mg/L]相比,差异具有显著性意义(P<0.01);与PNDs组[SP(270.98±36.25)mg/L、CGRP(362.13±73.67)mg/L]相比,差异亦具有显著性意义(P<0.05);PNDs组SP和CGRP亦高于对照组,差异具有显著性意义(P<0.05);PNDs性咳嗽组治疗后SP降至(261.09±37.04)mg/L、CGRP降至(335.73±55.07)mg/L,与治疗前相比,差异具有非常显著性意义(P<0.01),与对照组的差异也具有显著性意义(P<0.05)。结论感觉神经肽参与了PNDs的发病过程,同时可能是PNDs引起慢性咳嗽的机制。
Objective To investigate the role of sensory neuropeptides in post-nasal drip syndrome (PNDs) cough patients. Methods Twenty-three patients with PNDs cough and 16 patients with PNDs were enrolled in Department of Respiratory Medicine, the First Affiliated Hospital of Jinan University from March 2004 to September 2005. Radioimmunoassay was used to detect substance P (SP) in sputum supernatant, Calcitonin gene-related peptide (CGRP) mass concentration, and another eight healthy adults as the control group. Results Compared with control group [SP (168.14 ± 56.97) mg / L and CGRP (227.69 ± 70.84) mg / L], the PNDs cough group had significantly higher levels of SP (345.14 ± 72.58 mg / L and CGRP 573.78 ± 210.96 mg / (P <0.01). Compared with PNDs group [SP (270.98 ± 36.25) mg / L and CGRP (362.13 ± 73.67) mg / L], the difference was also significant (P < 0.05). The levels of SP and CGRP in PNDs group were also significantly higher than those in control group (P <0.05). After PNDs cough group, SP decreased to (261.09 ± 37.04) mg / L and CGRP decreased to (335.73 ± 55.07 ) mg / L, the difference was significant compared with that before treatment (P <0.01), and the difference with the control group was also significant (P <0.05). Conclusions Sensory neuropeptides are involved in the pathogenesis of PNDs and may be the mechanism of chronic cough caused by PNDs.