论文部分内容阅读
B族链球菌(GBS)是引起围产期妇女及其新生儿严重感染的最常见病原体.为此作者对Ⅲ型GBS荚膜多糖(CPS)-破伤风类毒素(Ⅲ-TT)偶联菌苗在狒狒中的免疫原性进行了研究,以期通过这种非人类灵长目模型探讨母体 GBS CPS抗体的转移.作者将实验动物分成8组,每组3只狒狒,分别肌肉接种0.5ml的Ⅲ型CPS、TT或Ⅲ-TT.接种Ⅲ-TT的6组中3组加用性剂铝胶,另2组分别接种Ⅲ型CPS和TT.分别于接种前及接种后4、8、16、25、27、29、33和52周采血,用Ⅲ型放射性抗原结合法检测Ⅲ型CPS抗体.结果显示,仅接种Ⅲ-TT加铝胶狒狒的Ⅲ型特异性抗体几何平均浓度(GMAC)升
Group B Streptococcus (GBS) is the most common cause of severe infection in perinatal women and their newborns.Therefore, the author of the GBS capsular polysaccharide (CPS) - tetanus toxoid (Ⅲ-TT) The immunogenicity of seedlings in baboons was studied in order to explore the transfer of maternal GBS CPS antibodies using this non-human primate model.The authors divided the experimental animals into 8 groups of 3 baboons each with 0.5 ml of type III CPS, TT, or Ⅲ-TT. Six groups of Ⅲ-TT were treated with aluminum paste and three groups of CPS and TT were inoculated respectively with different doses of 4, 8, 16, 25 Blood samples were taken at weeks 27, 29, 33 and 52, and type III CPS antibodies were detected by radioactive antigen type III assay. The results showed that the geometric mean concentration (GMAC) of type III specific antibody