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多发性骨髓瘤(MM)是一种较少见的浆细胞恶性增殖病。浆细胞恶性增生可导致患者血清中出现大量而均一的某一种类Ig(M蛋白),浓度可达2g％以上,而其余各类Ig降低或保持正常低值。我们用醋酸纤维膜电泳和免疫电泳进行了试验,前一方法可以定量,但灵敏度不高,后一种方法灵敏度高,可以查出前者不能反应出来的异常免疫球蛋白,包括单细胞系异常Ig、多细胞系Ig及免疫缺陷病。MM属于单细胞系异常1g之一。我院在1985—1986年遇到两例,报道如下:
Multiple myeloma (MM) is a rare plasma cell malignant proliferative disease. Plasma cell malignant hyperplasia can lead to the emergence of a large number of patients with a homogeneous and homogeneous type of Ig (M protein), the concentration of up to 2g% above, while the remaining types of Ig reduce or maintain normal low value. We used acetate membrane electrophoresis and immunoelectrophoresis experiments, the former method can be quantitative, but the sensitivity is not high, the latter method is highly sensitive, you can detect the former can not be out of the abnormal immunoglobulin, including single-cell abnormal Ig , Multicellular Ig and immune deficiency disease. MM is one of single cell abnormalities 1g. In our hospital from 1985 to 1986 met two cases, reported as follows: