论文部分内容阅读
目的探讨10d内已退热的川崎病(KD)患儿应用丙种球蛋白(IVGG)治疗的必要性以及不同剂量IVGG治疗对KD预后的影响。方法研究对象为1999-10—2005-10山东省菏泽市立医院收治的56例KD患儿,所有患儿均为10d内退热后确诊且无冠脉病变。按IVGG治疗剂量分成3组,A组(11例)用1g/kg,B组(26例)用2g/kg,C组(19例)未使用,余治疗相同。对其冠状动脉损害(CAL)情况进行对比。结果病程14~21d时发生CAL例数:A组2例(18·18%),B组4例(15·38%),C组16例(84·21%),A、B组比较差异无显著性意义(P>0·05);A、B组与C组之间差异有非常显著性意义(P<0·01)。随访0·5年CAL例数:A组1例(9·09%),B组1例(3·85%),C组11例(57·89%),A、B组比较差异无显著性意义(P>0·05),而A、B组与C组之间差异有非常显著性意义(P<0·01)。结论10d内一经确诊的KD无论是否已退热均应给予IVGG治疗,对已退热且无冠脉损害的患儿应用总量1g/kg IVGG治疗可以达到满意的效果。
Objective To investigate the necessity of using gammaglobulin (IVGG) in children with Kawasaki disease (KD) that have been experiencing fever within 10 days and the effects of different doses of IVGG on the prognosis of KD. Methods The subjects were 56 KD children admitted to Heze Municipal Hospital of Shandong Province from October 1999 to October 2005. All patients were diagnosed with fever and no coronary lesions within 10 days after fever. Divided into three groups according to IVGG treatment dose, group A (11 cases) with 1g / kg, group B (26 cases) with 2g / kg, group C (19 cases) were not used, the remaining treatment the same. Coronary artery lesions (CAL) were compared. Results There were 2 cases (18.18%) in group A, 4 cases (15.38%) in group B, 16 cases (84.21%) in group C, There was no significant difference (P> 0.05). There was significant difference between group A and group B (P <0.01). The follow-up of 0.5 years of CAL cases: 1 case (9 · 09%) in group A, 1 case (3 · 85%) in group B and 11 cases (57 · 89%) in group C (P> 0.05), while there was a significant difference between group A, group B and group C (P <0.01). CONCLUSIONS: Once diagnosed KD within 10 days should be treated with IVGG, whether or not antipyretic, and satisfactory results can be achieved by using IVGG at a dose of 1 g / kg in children with fever and no coronary artery lesions.