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腹主动脉瘤的发病机制尚无定论,通过对人病变组织及小鼠模型的研究发现,主要的发病机制有基质金属蛋白酶降解机制、动脉壁炎症机制及氧化应激机制。本文回顾了近20年研究其发病机制的国内外文献,主要对这3种机制涉及的分子机制的相关进展进行介绍。
The pathogenesis of abdominal aortic aneurysm is inconclusive. The study of human diseased tissue and mouse model found that the main pathogenesis is the mechanism of matrix metalloproteinase degradation, arterial wall inflammation and oxidative stress. This article reviews the domestic and foreign literatures about the pathogenesis in recent 20 years and mainly introduces the related molecular mechanisms involved in these three mechanisms.