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目的:对比观察重度烧伤患者补充核黄素后核黄素营养状况和血清总抗氧化水平的变化。方法:将入院治疗的重度烧伤患者随机分成补充核黄素组和未补充核黄素组,每组各30例。补充核黄素组患者于伤后第3天补充核黄素,每次口服(或经鼻胃管)核黄素10mg,每日3次,连续补充2周。分别于伤后1～3d、6～8d和13～15d,测定红细胞谷胱甘肽还原酶活性系数和血清总抗氧化能力。结果:重度烧伤患者补充核黄素后10～12d(即伤后第13～15天),补充核黄素组核黄素营养缺乏例数明显少于未补充核黄素组,差异有统计学意义(P<0.01);补充核黄素组患者血清总抗氧化水平高于未补充核黄素组(P<0.01)。结论:重度烧伤患者伤后2周内每日补充30mg核黄素能明显改善核黄素营养缺乏状况并能提高患者血清总抗氧化能力。
OBJECTIVE: To compare the changes of riboflavin nutrition status and serum total antioxidant capacity after riboflavin supplementation in patients with severe burn. Methods: The patients with severe burn admitted to hospital were randomly divided into supplemented riboflavin group and non-supplemented riboflavin group, 30 cases in each group. Riboflavin supplemented with riboflavin on the 3rd day after injury was given to the riboflavin group. Each time oral (or nasogastric tube) riboflavin 10mg, 3 times a day for 2 weeks. Respectively 1 ~ 3d, 6 ~ 8d and 13 ~ 15d after injury, the erythrocyte glutathione reductase activity coefficient and serum total antioxidant capacity were measured. Results: In the group of severe burn patients, riboflavin supplementation with riboflavin 10 to 12 days (ie, 13 to 15 days after injury), riboflavin supplementation with riboflavin deficiency was significantly less than the number of cases without supplementation with riboflavin, the difference was statistically significant (P <0.01). The serum total antioxidant capacity of patients in the group supplemented with riboflavin was higher than that in the group without riboflavin (P <0.01). CONCLUSION: The daily supplementation of 30 mg riboflavin within 2 weeks after injury in severely burned patients can significantly improve the condition of riboflavin deficiency and improve the total serum antioxidant capacity.