目的了解邹城市6824人接种乙肝疫苗后的免疫水平,为制定更完整有效的免疫策略,进一步做好乙肝防治工作提供科学依据。方法以个人自愿为原则,监测乙肝表面抗原和抗体后进行3针次乙肝疫苗免疫接种,并于接种完成一个月后进行乙肝表面抗原和抗体的测定。结果按免疫接种程序和接种技术操作规程及时接种乙肝疫苗6824人,乙肝表面抗体阳性率为81.62%。结论按目前乙肝疫苗免疫接种程序,预防接种后,抗体的阳转率随年龄的增加而降低。 Objective To understand the immunization level of 6824 people in Zoucheng City after Hepatitis B vaccination and to provide a scientific basis for making a more complete and effective immunization strategy and further doing prevention and control of Hepatitis B disease. Methods Based on the principle of individual voluntariness, hepatitis B surface antigen and antibody were monitored after immunization with 3 doses of hepatitis B vaccine and hepatitis B surface antigen and antibody were measured one month after the vaccination was completed. Results According to the vaccination procedure and inoculation technique, 6824 hepatitis B vaccination patients were vaccinated in time. The positive rate of HBsAg was 81.62%. Conclusions According to the current hepatitis B vaccine immunization program, after immunization, the positive rate of antibody decreases with age.