Is there A Link between Serum Thyroid Stimulating Hormone Level and the Results of in vitro Fertiliz

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Objective To analyze the clinical features and outcomes in infertile patients with different levels of thyroid stimulating hormone (TSH) undergoing IVF/ICSI,and to investigate whether inappropriate level of TSH has the adverse effect on the results of the IVF-ET.Methods A total of 389 patients undergoing IVF/ICSI from January 2009 to December 2011 were divided into 3 groups according to the basal TSH level:group A (TSH<2.0 mIU/L),group B (TSH 2.0-4.5 mIU/L) and group C (TSH>4.5 mIU/L).Oocyte retrieved,fertilization rate,cleavage rate,available embryo rate,pregnancy rate and miscarriage rate were analyzed to explore whether serum TSH level was correlated with the results of IVF/ICSI.Results There were no differences in number of oocyte retrieved,fertilization rate,cleavage rate and available embryo rate among 3 groups (P>0.05).Clinical pregnancy rate in group B (43.0%) was significantly higher than that in group A (30.2%) and group B (23.5%),respectively (P<0.05).There were no significant differences in miscarriage rate among 3 groups.Conclusion TSH level has no effect on fertility rate or miscarriage rate in patients undergoing IVF/ICSL Inadequacy TSH level would decrease the IVF/ICSI pregnancy rate.
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