近年来,我国肺癌发病率和病死率呈显著上升趋势,60%~85%肺癌患者发现时已属晚期,无法进行根治性手术切除。表皮生长因子受体(EGFR)基因突变状态已成为晚期肺腺癌指导治疗和判断预后的重要指标,但目前突变特异性扩增系统(ARMS)技术检测肺癌实体瘤EGFR基因突变情况,大部分是在手术活检标本上应用,传统的细胞学制片技术普遍存在不易于观察、阳性检出率低、样本无法长期保存等诸多缺点。本文采用肺腺癌胸水肿瘤细胞制成细胞蜡块,进行免疫组化检测和ARMS技术检测肺腺癌瘤细胞 In recent years, the incidence of lung cancer and mortality in China showed a significant upward trend, 60% to 85% of patients with lung cancer is already late, and can not be a radical surgical resection. Epidermal growth factor receptor (EGFR) gene mutation status has become an important indicator of advanced lung adenocarcinoma treatment and prognosis, but the current mutation-specific amplification system (ARMS) detection of EGFR gene mutations in lung cancer solid tumors, most of them Application in surgical biopsy specimens, the traditional cytology production techniques are not easy to observe, the positive detection rate is low, the sample can not be long-term preservation and many other shortcomings. In this paper, lung adenocarcinoma of pleural effusion cells made of wax cells, immunohistochemistry and ARMS detection of lung adenocarcinoma cells