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组蛋白样蛋白 (Histone likeprotein ,HlpA)存在于多种链球菌中 ,在生理状态下与细菌染色质相结合。中性粒细胞可使HlpA从菌体中释放出来[1 ] ,成为链球菌感染引起的心内膜炎、风湿性心肌炎和肾小球肾炎等疾病的一个毒力因素 ,在病变局部引起炎症和免疫病理反应[2 ] 。链球菌与
Histone-like protein (HlpA) is present in a variety of Streptococcus and binds to bacterial chromatin under physiological conditions. Neutrophils can HlpA released from the cell [1], a streptococcal infection caused endocarditis, rheumatoid myocarditis and glomerulonephritis and other diseases, a virulence factor in the lesions caused by inflammation and Immunopathological reactions [2]. Streptococcus and