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目的探讨骨桥蛋白(osteopontin,OPN)在子宫内膜样腺癌组织中的表达及与子宫内膜样腺癌临床病理特征和患者预后之间的关系。方法采用免疫组化方法检测OPN在46例子宫内膜样腺癌组织、16例正常子宫内膜组织中的表达。结果 OPN在子宫内膜样腺癌组织中的表达明显高于正常子宫内膜;OPN在低分化组织中的表达明显高于中分化组织。OPN阳性组的累积生存率明显低于阴性组,多因素分析显示OPN阳性表达是影响子宫内膜样腺癌患者生存时间的独立因素。结论 OPN与子宫内膜样腺癌的发生和预后密切相关,OPN可作为判断子宫内膜样腺癌患者预后的指标之一。
Objective To investigate the expression of osteopontin (OPN) in endometrioid adenocarcinoma and its relationship with the clinicopathological features and prognosis of endometrioid adenocarcinoma. Methods Immunohistochemistry was used to detect the expression of OPN in 46 cases of endometrioid adenocarcinoma and 16 cases of normal endometrium. Results The expression of OPN in endometrial adenocarcinoma was significantly higher than that in normal endometrium. The expression of OPN in poorly differentiated tissues was significantly higher than that in moderately differentiated tissues. The cumulative survival rate of OPN-positive group was significantly lower than that of negative group. Multivariate analysis showed that OPN-positive expression was an independent factor affecting the survival time of patients with endometrioid adenocarcinoma. Conclusion OPN is closely related to the occurrence and prognosis of endometrioid adenocarcinoma. OPN can be used as one of the prognostic indicators in endometrioid adenocarcinoma.