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目的:探讨复方丹参注射液Ⅱ的制备及其指标成分丹酚酸B在大鼠体内的含量测定方法。方法:通过羟丙基-β-环糊精包合增加降香挥发油溶解性;用HPLC法测定主成分丹酚酸B在大鼠体内的含量。结果:成功制备复方丹参注射液Ⅱ,建立注射液中指标成分丹酚酸B在大鼠体内的HPLC测定方法。结论:复方丹参注射液Ⅱ的制备工艺可行,指标成分丹酚酸B在大鼠体内的含量测定方法准确可靠。
Objective: To investigate the preparation of compound Salvia miltiorrhiza injection Ⅱ and the method of determining the content of salvianolic acid B in rat. Methods: The solubility of essential oil of Rhizoma Dioscorea was improved by inclusion of hydroxypropyl-β-cyclodextrin. The content of salvianolic acid B in rat was determined by HPLC. Results: The compound Danshen Injection Ⅱ was successfully prepared, and the HPLC method was established for the determination of Salvianolic acid B in the injection. Conclusion: The preparation process of Compound Danshen Injection Ⅱ is feasible. The determination method of Salvianolic acid B is accurate and reliable in rats.