卡那霉素与利尿酸(Ethacrynic acid)同时使用,因交互作用引起永久性听力损伤者,在临床与动物实验均已证实,特别是大剂量应用时,短期内就能引起严重的永久性听力损伤。速尿与利尿酸的化学结构不同,但在肾脏内的作用颇为相似。速尿在人体引起暂时性听力损伤者已有报告,但与卡那霉素同时应用发生交互作用引起永久性耳聋者尚未见有报导。本研究之目的是通过动物实验观察二者能否产生交互作用而导致永久 Kanamycin and Ethacrynic acid (Ethacrynic acid) at the same time, due to interaction caused permanent hearing impairment, both clinical and animal experiments have confirmed, especially in high-dose applications, can cause severe short-term permanent hearing damage. The furosemide and diuretic have different chemical structures, but their roles in the kidney are quite similar. Furosemide has been reported to cause transient hearing loss in the human body. However, there has been no report of permanent deafness caused by the interaction with kanamycin. The purpose of this study is to observe whether the interaction between the two can lead to permanent