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白介素-21(IL-21)是近年来被发现和关注的一个四螺旋束的细胞因子,主要由活化的CD4_+T细胞和自然杀伤细胞分泌产生,对免疫球蛋白产生和B细胞终末分化起着关键作用。它的受体属于I型细胞因子受体,广泛分布于T细胞、B细胞、NK细胞、树突状细胞等表面。IL-21具有多效性,在系统性红斑狼疮(SLE)、类风湿关节炎、炎症性肠病等自身免疫性疾病的发病机制中起作用。本文就IL-21与SLE的关系作一综述。
Interleukin-21 (IL-21) is a four-helix bundle cytokine discovered and focused in recent years. It is secreted mainly by activated CD4 + T cells and natural killer cells and plays an important role in immunoglobulin production and B cell terminal differentiation Play a key role. Its receptor belongs to type I cytokine receptors, widely distributed in T cells, B cells, NK cells, dendritic cells and other surfaces. IL-21 is pleiotropic and plays a role in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis and inflammatory bowel disease. This article reviews the relationship between IL-21 and SLE.