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肥胖在全世界范围内流行,人们希望出现一种安全有效的治疗药物来对付肥胖。遗憾的是,目前只有一种药物,奥利司他(orlistat),符合“安全有效”这个要求,但是此药持续减肥效果的时间太短,根本无法满足临床要求。最近,人们在能量平衡控制领域有了新进展,为治疗肥胖提供了许多治疗新靶点。一些以减肥为目的的措施,已在临床试验中获得了可喜的成绩。然而,平衡减肥药物的疗效和安全性,具有挑战性。未来的减肥新药,需要具有创新性、更好的有效性和更好的耐受性。因此,本文回顾了目前可用的减肥药物,阐述了一些减肥治疗失败的原因,并讨论了未来减肥新药的发展战略。
The prevalence of obesity in the world, people want a safe and effective treatment for obesity. Unfortunately, there is only one drug, orlistat, that meets the “safe and effective” requirement, but the drug’s sustained weight loss effect is too short to meet clinical requirements. Recently, there has been new progress in the field of energy balance control, which has provided many new therapeutic targets for the treatment of obesity. Some measures aimed at weight loss have achieved gratifying results in clinical trials. However, balancing the efficacy and safety of diet pills is challenging. Future weight loss drugs need to be innovative, better effective and better tolerated. Therefore, this article reviews currently available weight-loss medications, explains some of the reasons why weight loss treatments failed, and discusses future strategies for the development of new weight-loss medicines.