血卟啉衍生物(HpD)作为光敏剂与激光技术相结合应用于临床治疗浅表肿瘤已取得显著的疗效。但是,HpD能否作为辐射增敏剂治疗深部肿瘤亦已引起人们的重视。本文报告了离体培养的HeLa细胞经HpD(30微克/毫升)处理后接受X线(5 Gy)照射,观察其某些生物学特性的改变,并以此作为判断HpD的辐射增敏效应的指标。实验结果表明,HeLa细胞经HpD处理后可提高辐射敏感性(SER)10—67.7%。 Hematoporphyrin derivative (HpD) as a photosensitizer and laser technology has been applied in the clinical treatment of superficial tumors has achieved significant results. However, whether HpD can be used as a radiation sensitizer to treat deep tumors has also attracted people’s attention. This article reports that in vitro cultured HeLa cells were treated with HpD (30 μg/ml) and irradiated with X-rays (5 Gy) to observe changes in some of their biological characteristics, which were used as a measure of the radiation sensitization effect of HpD. index. The experimental results show that HeLa cells can improve radiation sensitivity (SER) 10-67.7% after HpD treatment.