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多烯大环内酯抗菌素由于水溶性差和毒性大使其应用受到限制,本文报导了多烯大环内酯抗菌素的一类新的溶解性能较好而保持原有生物活性的衍生物。
Because of their poor water solubility and toxicity, the polyene macrolide antibiotics are limited in their applications. In this paper, a new class of polyene macrolide antibiotics is reported to have better solubility and maintain the original biological activity.