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目的探讨慢性心力衰竭患者校正QT间期(QTc)与QT离散度(QTd)及心功能超声参数相互关系。方法研究了141例左室射血分数(LVEF)<50%的慢性心力衰竭患者QTc与QRS间期、临床指标、心脏超声心动图参数的相关性。结果QTc与年龄(r=0.22,P<0.01)、左室舒张末期直径(r=0.25,P<0.01)、左房直径(r=0.23,P<0.01)、QRS间期(r=0.36,P=0.01)、QTd(r=0.42,P<0.01)呈正相关;与短轴缩短率(r=-0.27,P<0.01)、LVEF(r=-0.34,P<0.01)呈负相关;与二尖瓣E波和A波峰值速度比值、等容舒张时间无相关性(P>0.05)。多元回归分析显示,QTC和QTd、QRS间期、LVEF存在独立相关性。结论QTC与心力衰竭患者预后影响因素相关;QTC与QTd存在独立相关性,可作为慢性心力衰竭预后较好的预测指标。
Objective To investigate the relationship between QTc (QTc) and QTd (QTd) and cardiac function parameters in patients with chronic heart failure. Methods The correlation between QTc, QRS interval, clinical parameters and echocardiographic parameters of echocardiography in 141 patients with LVEF <50% was studied. Results QTc was positively correlated with age (r = 0.22, P <0.01), left ventricular end diastolic diameter (r = 0.25, P <0.01), left atrium diameter (r = (P = 0.01), QTd (r = 0.42, P <0.01), but negative correlation with shortening rate of short axis (r = -0.27, P <0.01) and LVEF Mitochondrial E wave and A wave peak velocity ratio, isovolumic relaxation time was not related (P> 0.05). Multivariate regression analysis showed that there was independent correlation between QTC and QTd, QRS interval and LVEF. Conclusions QTC is associated with prognostic factors in patients with heart failure. QTC is independently associated with QTd and may be used as a predictor of prognosis in patients with chronic heart failure.