论文部分内容阅读
早在1912年人们就提出用家兔来检查注射用药品中的发热物质,1942年美国药典12版首次收载该法,随后世界各国药典相继收载这一方法,并不断发展至今,成为经典的热原检查方法。家兔法的优点是能反映热原引起的哺乳动物复杂的升温过程,但不易定量,重现性和灵敏度差,费用高且费时
As early as 1912, people proposed that rabbits should be used to examine the fever substances in injectable drugs. The first edition of the United States Pharmacopeia, version 12, contained this method in 1942, and then the pharmacopoeias of all countries in the world took this method one after another, and continue to evolve into a classic Pyrogen test method. The advantage of the rabbit method is that it can reflect the complex heating process in mammals caused by pyrogen, but it is not easy to quantify, reproducibility and sensitivity are poor, it is expensive and time-consuming