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目的:研究同源重组修复相关基因Rad52在鼻咽癌组织中的表达并探讨其临床意义。方法:采用免疫组织化学三步法检测38例鼻咽癌患者癌组织及其相应存在的癌旁组织的Rad52蛋白的表达,并比较其表达结果,分析癌组织中Rad52的表达与患者的临床资料(如性别、年龄、临床分期等)的关系。结果:鼻咽癌组织与癌旁黏膜的Rad52蛋白表达相比差异有统计学意义(P<0.05)。Spearman等级相关分析显示,癌组织中Rad52蛋白表达情况与患者的临床分期呈负相关性(P<0.05),而与患者的性别、年龄、复发率、淋巴结转移率等无显著相关性(P>0.05);生存分析显示,Rad52蛋白的高表达对患者的生存时间有显著影响(P<0.05)。结论:Rad52蛋白对鼻咽癌患者的治疗效果及预后评估有重要意义。
Objective: To study the expression of homologous recombination-related gene Rad52 in nasopharyngeal carcinoma and its clinical significance. Methods: Immunohistochemical three-step method was used to detect the expression of Rad52 protein in 38 cases of nasopharyngeal carcinoma and its corresponding paracancerous tissues. The expression of Rad52 protein in cancer tissue was compared with the clinical data of the patients (Such as gender, age, clinical stage, etc.) relationship. Results: The expression of Rad52 in nasopharyngeal carcinoma tissue was significantly different from that in adjacent mucosa (P <0.05). Spearman rank correlation analysis showed that the expression of Rad52 in cancer tissues was negatively correlated with the clinical stage (P <0.05), but not with the gender, age, recurrence rate and lymph node metastasis (P> 0.05). Survival analysis showed that the high expression of Rad52 protein had a significant effect on the survival time of patients (P <0.05). Conclusion: Rad52 protein is of great significance for the treatment and prognosis evaluation of patients with nasopharyngeal carcinoma.