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Swenson首先发现“巨结肠”中外观正常的远侧肠道起着功能性梗阻的作用,将其切除后可使肠道功能恢复正常,因而“巨结肠”是正常肠道对远侧梗阻的反应性扩张。病理学家也证实远端肠道恒定有神经节细胞缺乏。Okamoto的胚胎学研究又证明正常神经节细胞由神经嵴移入肠道按头侧至尾侧方向进行,巨结肠看来是这一过程未进展至肛管上缘即告停止的结果。本文内容为作者1949年～1982年间处理372例巨结肠的经验。处理 1967年曾复习155例巨结肠,多数作Swenson式结肠直肠切除。为避免在腹内切开肠道,采用了Browne改良法;有些用Duhamel、
Swenson first found that the normally appearing distal gut in Hirschsprung plays a role in functional obstruction, allowing gut back to normalize gut function so that “megacolon” is the response of the normal gut to distal obstruction Sexual expansion. Pathologists also confirmed that there is a constant lack of ganglion cells in the distal gut. Okamoto’s embryological studies have shown that normal ganglion cells migrate from the neural crest to the intestine in the head-to-tail direction, and that the megacolon appears to be the result of the process, which did not progress to the upper edge of the anal canal. This article describes the experience of treating 372 cases of megacolon between 1949 and 1982. Treatment of 1967 had reviewed 155 cases of megacolon, most of Swenson-style colorectal resection. In order to avoid incision in the intestine of the intestine, using Browne improved method; some with Duhamel,