目的观察两性霉素 B 对血液病合并真菌感染的临床疗效及安全性。方法 30例血液病患者出现真菌感染时使用两性霉素 B,初始剂量5 mg/d,每日增加5～10 mg,加至25～35 mg/d 后维持治疗,用药7～63 d,中位数30 d;加入5%葡萄糖500 mL 中输液泵避光均速8 h泵入。结果两性霉素 B 临床总有效率为73.3%,副反应:寒战、发热 Objective To observe the clinical efficacy and safety of amphotericin B against blood-borne fungal infections. Methods Amphotericin B was used in 30 patients with hematological diseases for fungal infection. The initial dose of 5 mg / d was 5 ~ 10 mg daily. When the dose of amphotericin was increased to 25 ~ 35 mg / d, the treatment was maintained for 7 ~ 63 d Median 30 d; adding 5% glucose 500 mL in the infusion pump were light-fast 8 h pump. Results amphotericin B clinical total effective rate was 73.3%, side effects: chills, fever