论文部分内容阅读
目的研究自体骨髓间充质干细胞移植方案,治疗严重脑外伤后遗症患者的可行性及临床效果。方法回顾性分析2011年3月-2013年10月本院26例严重脑外伤后遗症患者,依据患者个人意愿选择治疗方案,分为干细胞移植治疗组(n=14)和常规治疗对照组(n=12)。结果干细胞移植患者术后平均住院10 d。为期1个月的治疗结束6个月后,对所有患者功能独立性方面进行评分和对比研究。结果表明,干细胞移植组患者在生活自理能力、活动能力、行动能力、理解交流能力、社会认知能力及总分方面较治疗前差异有统计学意义(P<0.05)。移植组在治疗后1个月、3个月、6个月时NIHSS评分差异有统计学意义(P<0.05),而对照组无此效果。结论自体骨髓间充质干细胞移植术在治疗严重脑外伤后遗症方面有较好的临床疗效,在其他脑损伤,如脑缺血、脑出血等脑内伤方面可能同样有效。
Objective To study the feasibility and clinical efficacy of autologous bone marrow mesenchymal stem cell transplantation in the treatment of patients with severe traumatic brain injury. Methods A retrospective analysis of 26 patients with severe traumatic brain injury sequelae from March 2011 to October 2013 in our hospital was conducted. Patients were selected according to their wishes and were divided into three groups: the stem cell transplantation group (n = 14) and the conventional treatment group (n = 12). Results The average postoperative hospital stay of stem cell transplantation was 10 days. Six months after the end of the one-month treatment, all patients were scored and compared for functional independence. The results showed that the patients in stem cell transplantation group had statistically significant differences (P <0.05) in self-care ability, activity ability, mobility, understanding of communication ability, social cognitive ability and total score. The NIHSS score in the transplantation group at 1 month, 3 months and 6 months after treatment was significantly different (P <0.05), but not in the control group. Conclusion Autologous bone marrow mesenchymal stem cell transplantation has a good clinical efficacy in the treatment of severe traumatic brain injury sequelae and may be equally effective in other brain injuries such as cerebral ischemia and cerebral hemorrhage.