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麻醉镇痛剂芬太尼(FT)是一种苯哌啶衍生物.它具有脂溶性高、分子量小,透皮效能强等特点,故适用于透皮使用。药动学 FT透皮吸收后进入皮下,储存于上皮层。斑贴2小时,血浆中FT浓度几乎不能检出。斑贴8～12小时,血浆中浓度大约与静脉滴注FT剂量相当。经皮释放上FT,以相对恒定的血浆浓度维持止痛达72小时。FT广泛分布于哺乳动物的器官和组织,包括
The narcotic analgesic fentanyl (FT) is a derivative of phenylpiperidine, which has the characteristics of high fat solubility, low molecular weight and strong transdermal efficacy and is therefore suitable for transdermal application. Pharmacokinetics FT transdermal absorption into the skin, stored in the epithelial layer. Patch 2 hours, the plasma FT concentration almost can not be detected. Patch 8 to 12 hours, the plasma concentration is about the same as the intravenous infusion of FT dose. Percutaneous release on FT, analgesia was maintained for 72 hours at a relatively constant plasma concentration. FT is widely distributed in mammalian organs and tissues, including