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目的分析儿童肌阵挛性癫痫的临床特点与疗效。方法回顾性分析山西省昔阳县人民医院1990-2005年诊治35例儿童肌阵挛性癫痫的临床资料,对其临床特点与治疗效果进行分析。结果7例(20%)患儿有癫痫家族史,11例(31.4%)有高热惊厥史。睡眠及闪光诱发脑电图检查可提高癫痫的检出率。6例治疗中出现病情加重倾向,2例重症肌阵挛性癫痫死亡,应用丙戊酸钠单药治疗28例(80%)效果满意。结论儿童肌阵挛性癫痫易误诊误治,小剂量丙戊酸钠治疗效果好。重症儿童肌阵挛性癫痫预后差,病死率高。
Objective To analyze the clinical features and therapeutic effects of myoclonic epilepsy in children. Methods The clinical data of 35 cases of myoclonic epilepsy diagnosed and treated in Xiyang County People’s Hospital of Shanxi Province from 1990 to 2005 were analyzed retrospectively. The clinical features and therapeutic effects were analyzed. Results Seven patients (20%) had a family history of epilepsy and 11 patients (31.4%) had history of febrile seizures. Sleep and flash-induced electroencephalography can improve the detection rate of epilepsy. In 6 cases, the disease tended to aggravate, and 2 patients died of severe myoclonic epilepsy. 28 cases (80%) were treated with sodium valproate monotherapy and the results were satisfactory. Conclusions Children with myoclonic epilepsy are often misdiagnosed and mistakenly treated with low dose sodium valproate. Severe childhood myoclonic epilepsy poor prognosis, high mortality.