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1942年 Hobby 等在体外研究青霉素对溶血性链球菌的作用时发现了约有1%的菌在适当的药物浓度下能存活下来,并注意到药物对积极繁殖的菌作用最强。1957年 Mc Dermott 对细菌残存现象的临床和实验提出综合观点。大约在同时,有人在结核病治疗中发现了类似的现象。作者综合大量的实验和临床的资料提出了菌的残存现象和残存菌的概念。所谓残存菌是指宿主虽经适当的化疗,但在其
In 1942, Hobby et al. Observed that the effect of penicillin on hemolytic streptococcus in vitro showed that about 1% of the bacteria could survive at the appropriate drug concentration, and noted that the drug had the strongest effect on the actively propagated bacteria. In 1957, McDermott put forward a comprehensive view of the clinical and experimental bacterial residual phenomena. Around the same time, a similar phenomenon was observed in the treatment of tuberculosis. Based on a large amount of experimental and clinical data, the author proposed the concept of residual bacteria and residual bacteria. The so-called residual bacteria refers to the host despite the appropriate chemotherapy, but in its