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本文摘自一汇编,介绍非甾体抗炎新药 napro-xen,涉及化学、药理、临床等各方面,共15篇文章。Naproxen 化学名为 d-2-(6′-甲氧基-萘-2′)-丙酸。合成法如下:2-甲氧基萘以乙酰氯行 Friedel-Crafts 反应得2-乙酰基-6-甲氧基萘,后者以 Willgerodt-Kindler 反应得6-甲氧基萘-2-乙酸,将此酸以甲醇-硫酸酯化得相应的酯,然后以氢化钠、碘
This article is an excerpt from a compilation of non-steroidal anti-inflammatory drugs introduced napro-xen, involving chemistry, pharmacology, clinical and other aspects, a total of 15 articles. Naproxen Chemical name is d-2- (6’-methoxy-naphthalene-2 ’) - propionic acid. The synthesis method is as follows: 2-Methoxynaphthalene was subjected to Friedel-Crafts reaction with acetyl chloride to obtain 2-acetyl-6-methoxynaphthalene. The latter was subjected to Willgerodt-Kindler reaction to give 6-methoxynaphthalene- This acid is methanol-sulfuric acid esterified to the corresponding ester, followed by sodium hydride, iodine