头孢哌酮(cefoperazone)是一个新型第三代头孢菌素,具有广泛的抗菌活性,对多种革兰氏阴性杆菌需氧或厌菌,尤其是对多价耐药的绿脓杆菌具有较强的抗菌作用。本文报道用微量法(微量稀释及棋盘法)测定头孢哌酮与氧哌嗪青霉素、青霉烷砜,妥布霉素及庆大霉素单用和合用对20株多价耐药性绿脓杆菌的协合抗菌作用。本实验菌株系选用对庆大 Cefoperazone is a new third-generation cephalosporin with a broad range of antibacterial activity that is aerobic or bacteriocidal against a wide range of Gram-negative bacilli, especially against polyvalent drug resistant Pseudomonas aeruginosa Antibacterial effect. This article reports the use of micro-method (micro-dilution and checkerboard method) of cefoperazone and piperacillin penicillin, penicillin sulfone, tobramycin and gentamicin alone and in combination on the 20 multi-drug resistant pus Bacillus synergistic antibacterial effect. The experimental strains selected on the celebration