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本文通过对61例球样异型增生的石蜡连续切片观察,将人胃粘膜球样异型增生分为两个主要组织病理学类型。通过对其背景及伴随病变的分析,发现球样异型增生与不全肠上皮化生,慢性萎缩性胃炎和印戒细胞癌关系密切。通过对球样异型增生细胞发生部位和存在形式的分析得出:Ⅰ型球样异型增生起源于胃粘膜固有上皮D型(Dissociative tyre cell)细胞;Ⅱ型球样异型增生细胞来自不全肠上皮化生上皮的结论。提出人胃粘膜球样异型增生和印戒细胞癌的组织发生假说,认为球样异型增生可能是印戒细胞癌的重要癌前病变。
In this paper, 61 patients with spherical dysplasia were observed by serial sectioning, and the gastric dysplasia was divided into two main histopathological types. Based on the analysis of its background and accompanying lesions, it was found that spherical dysplasia was associated with incomplete intestinal metaplasia, chronic atrophic gastritis and signet-ring cell carcinoma. Through the analysis of the site and presence of globular dysplasia cells, it is concluded that type I dysplasia originates from dissociative tyre cell type D; type II dysplasia cells from incomplete intestinal epithelialization Epithelial conclusions. The hypothesis of hypoplasia of gastric dysplasia and signet-ring cell carcinoma was proposed. It is considered that dysplasia may be an important precancerous lesion of signet-ring cell carcinoma.