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为探讨白细胞介素与癫痫发病机理的关系，该研究应用脑电图仪记录了侧脑室内注射白细胞介素－２（ＩＬ－２）后，大鼠海马脑电图的变化。结果显示：侧脑室内注射ＩＬ－２后，大鼠海马脑电图出现阵发性痫性放电，表现为频发棘波；应用免疫组织化学方法（ＰＡＰ法）和显微图像分析技术，观察到：侧脑室内注射ＩＬ－２后，大鼠海马回和齿状回内胶质原纤维酸性蛋白（ＧＦＡＰ）免疫反应的胶质细胞的数量明显增多、胞体截面积增大、突起及其分支增多。对大鼠海马回ＣＡ１区ＧＦＡＰ免疫反应的胶质细胞进行显微图像分析，结果显示；与正常对照组相比，ＩＬ－２组的细胞数量约增加０．４８倍、胞体截面积约增加１．７３倍、周长约增加１．０９倍、平均光密度约增加０．２０倍、积分光密度约增加２．３１倍。统计结果表明：差异有极显著性意义（Ｐ＜０．０１）。上述结果提示：大鼠侧脑室内注射ＩＬ－２可促进海马星形胶质细胞的增殖、肥大和细胞突起的萌芽。
In order to investigate the relationship between interleukin and epilepsy, we used electroencephalography to record the changes of EEG in rat hippocampus after intracerebroventricular injection of interleukin-2 (IL-2). The results showed that intracerebroventricular injection of IL-2, epileptiform discharge in rats hippocampus epileptiform discharge, manifested as frequent spikes; using immunohistochemistry (PAP method) and microscopic image analysis techniques To: The intracerebroventricular injection of IL-2, the rat hippocampus and dentate gyrus glial fibrillary acidic protein (GFAP) immune response glial cells increased significantly, cell body cross-sectional area increased, the protruding and its branches increase. Microscopic image analysis of glial cells immunoreactive GFAP in hippocampus of hippocampus showed that compared with normal control group, the number of cells in IL-2 group increased by about 0.48-fold and the cell body cross-sectional area increased by about 1 .73 times, the circumference of about 1.09 times, the average optical density increased about 0.20 times, the integral optical density increased by 2.31 times. The statistical results show that there is a significant difference (P <0.01). These results suggest that intracerebroventricular injection of IL-2 can promote hippocampal astrocyte proliferation, hypertrophy and sprouting of cells.