正常大鼠脑组织Ca~(2+),Mg~(2+)-ATP酶活力为2.8±0.7 μmol/Pi mg protein·h。大鼠ip异丙肾上腺素5mg/kg 24h造成脑缺血,其Ca~(2+),Mg~(2+)-ATP酶活力升高至8.8±0.8 μmol/Pi mg protein·h。经地黄2或4g/kg po给药后,大鼠缺血脑Ca~(2+),Mg~(2+)-ATP酶活力分别降至6.8±0.8和5.8±0.7 μmol/Pj mg protein·h,表明地黄可防止脑组织缺血损伤和ATP耗竭,提示地黄中可能含有钙拮抗活性物质。 The activity of Ca~(2+) and Mg~(2+)-ATPase in normal rat brain was 2.8±0.7 μmol/Pi mg protein·h. Ischemia ip isoproterenol 5mg/kg 24h caused cerebral ischemia, and its Ca~(2+) and Mg~(2+)-ATPase activity increased to 8.8±0.8 μmol/Pi mg protein·h. After administration of Rehmannia 2 or 4g/kg po, the Ca 2+ ,Mg 2+ -ATPase activity in ischemic brain of rats decreased to 6.8±0.8 and 5.8±0.7 μmol/Pj mg protein, respectively. h, indicating that Rehmannia can prevent ischemic brain damage and ATP depletion, suggesting that rehmannia may contain calcium antagonistic active substances.