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目的:对比分析兰索拉唑和奥美拉唑配合抗生素等治疗酒精型消化溃疡的疗效,旨在为今后对酒精型消化溃疡的治疗提供相关参考。方法:选取我院96例Hp阳性酒精性消化溃疡患者,采用随机抽签法将其分为2组,每组48例,均给予常规抗生素治疗,在此基础上对照组加用兰索拉唑,治疗组加用奥美拉唑,4周围1疗程,对比分析两组患者的疗效。结果:疗程结束后,治疗组总有效率为95.83%稍高于对照组的93.75%,比较差异无统计学意义(χ2=0.2110;P=0.6460);治疗组Hp清除率为93.75%明显高于对照组的79.16%(χ2=4.3596,P=0.0368),治疗期间两组患者均未发生严重不良反应。结论:在治疗酒精型消化溃疡方面,兰索拉唑和奥美拉唑的治疗效果相当,但是兰索拉唑具有Hp清除率高、不良反应较少等优势,值得临床广泛推广使用。
Objective: To compare the efficacy of lansoprazole and omeprazole with antibiotics in the treatment of alcoholic peptic ulcer, and to provide reference for the treatment of alcoholic peptic ulcer in the future. Methods: A total of 96 Hp-positive patients with alcoholic peptic ulcer in our hospital were enrolled. The patients were divided into two groups by random sampling, with 48 cases in each group. All patients were given conventional antibiotics. On the basis of this, the patients in control group were treated with lansoprazole, The treatment group plus omeprazole, 4 weeks 1 course of treatment, comparative analysis of the efficacy of two groups of patients. Results: After treatment, the total effective rate of the treatment group was 95.83%, slightly higher than that of the control group (93.75%), the difference was not statistically significant (χ2 = 0.2110; P = 0.6460); the Hp clearance rate was 93.75% 79.16% of the control group (χ2 = 4.3596, P = 0.0368), no serious adverse reactions occurred in both groups during the treatment. Conclusion: Lansoprazole and omeprazole have similar therapeutic effect in the treatment of alcoholic peptic ulcer. However, lansoprazole has the advantages of high Hp clearance rate and fewer adverse reactions, which is worthy of wide application in clinic.