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用ＡＰＡＡＰ法检测６０例不同病期直肠癌患者外周血Ｔ细胞及其亚群的变化。结果表明直肠癌患者ＣＤ＋３、ＣＤ＋４细胞减少；ＣＤ＋８细胞Ａ、Ｂ两期改变不大，Ｃ期患者增加；ＣＤ＋４／ＣＤ＋８比值明显下降。放射治疗使ＣＤ＋３、ＣＤ＋８细胞下降；ＣＤ＋４细胞改变不大。放射线使细胞免疫功能下降，但能通过对直肠癌取得局部控制的同时，ＣＤ＋４／ＣＤ＋８比值失调有明显的改善尤其较早期患者。总之，Ｔ细胞及其亚群尤其ＣＤ＋４／ＣＤ＋８比值能较准确反应机体免疫状态，对肿瘤临床有一定的指导意义。
The APAAP method was used to detect the changes of peripheral blood T cells and their subgroups in 60 patients with rectal cancer. The results showed that the number of CD+3 and CD+4 cells decreased in patients with rectal cancer; the levels of A and B in CD+8 cells did not change significantly; the patients in stage C increased; the ratio of CD+4/CD+8 decreased significantly. Radiation therapy reduced CD+3 and CD+8 cells; CD+4 cells did not change much. Radiation reduces cellular immune function, but it can also achieve local control of rectal cancer. At the same time, the ratio of CD+4/CD+8 imbalance is significantly improved compared with early-stage patients. In short, the ratio of T cells and their subpopulations, especially CD+4/CD+8, can accurately reflect the immune status of the body and have a certain guiding significance for the clinical course of tumors.