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[目的]调查湖州地区门诊女性人乳头瘤病毒(HPV)感染状况及其基因型的流行谱。[方法]采用基因芯片技术对723例妇科门诊就诊女性宫颈分泌物进行23种HPV基因亚型检测,其中包括18种高危型(HPV16、18、31、33、35、39、45、51、52、53、56、58、59、66、68、73、83、MM4)和5种低危型(HPV6、11、42、43、44),分析其基因型的流行谱。[结果]723例女性共检出HPV阳性158例,感染率为21.85%。检出的HPV基因型有13种(HPV6、11、43、44、16、18、31、33、35、45、56、58、73),其中高危型以HPV16为主,其次为HPV58、18、33,低危型以HPV6、11型为主,高危型在HPV感染中占相当大的比重(79.29%)。不同年龄段HPV感染率以30岁以下组最高,其次为31～40岁组,随着年龄增长有下降趋势。[结论]湖州地区门诊就诊女性HPV感染并不少见,其常见基因型是16、33、58、18、6、11,高危型所占比例较高,对适当年龄段女性进行HPV感染筛查和及早治疗,有助于宫颈癌的防治。
[Objective] To investigate the prevalence and genotype of human papillomavirus (HPV) in outpatients in Huzhou area. [Methods] Twenty-three HPV genotypes were detected in 723 women with gynecological outpatients using gene chip technology, including 18 high-risk HPV types (HPV16,18,31,33,35,39,45,51,52 , 53,56,58,59,66,68,73,83, MM4) and five low-risk genotypes (HPV6, 11, 42, 43, 44). [Results] A total of 158 HPV positive cases were detected in 723 women, the infection rate was 21.85%. There were 13 HPV genotypes detected (HPV6, 11,43,44,16,18,31,33,35,45,56,58,73), of which the high-risk type was HPV16, followed by HPV58,18 33, low-risk type mainly HPV6, 11, high-risk type in HPV infection accounted for a large proportion (79.29%). The infection rate of HPV in different age groups was the highest in the group of 30 years old, followed by the group of 31-40 years old, with a downward trend with age. [Conclusion] The prevalence of HPV infection in outpatient clinics in Huzhou area is not uncommon. The common genotypes are 16, 33, 58, 18, 6 and 11, with a high proportion of high risk types. HPV infection screening in women of the appropriate age and Early treatment, contribute to the prevention and treatment of cervical cancer.