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目的研究复方远志合剂镇咳祛痰作用及评价其安全性。方法取昆明种健康小白鼠40只,体质量18～22g,雌雄各半,随机分成对照组,复方远志合剂低、中、高剂量组,采用氨水诱发小鼠咳嗽法和大鼠毛细管祛痰法,并通过急性毒性试验检验复方远志合剂的安全性。结果①复方远志合剂高、中、低剂量组均能使氨水致小鼠咳嗽潜伏期延长,咳嗽次数减少。其中高、中剂量组与生理盐水组比较差异有统计学意义(P<0.01);②复方远志合剂高、中、低剂量组均能使大鼠120min内排痰量增加,与生理盐水组相比,高、中剂量组差异有统计学意义(P<0.01);与氯化铵组比较,高剂量组差异无统计学意义,中、低剂量组差异有统计学意义(P<0.01)。结论复方远志合剂具有镇咳、祛痰的作用且安全性良好。
Objective To study the antitussive and expectorant effect of Fufang Yuanzhi Mixture and evaluate its safety. Methods Forty healthy Kunming mice were randomly divided into control group, low dose group, middle dose group and high dose group. The body weight was 18-22g, male and female were divided into control group, cough method induced by ammonia solution and rat expectorant method , And through the acute toxicity test compound Yuanzhi mixture safety. Results ① Compound Polygala Mixture high, medium and low dose groups can ammonia-induced mouse cough latency, cough frequency reduced. (P <0.01). ②Compound Polygala tenuifolia mixture in high, medium and low dose groups can make the amount of sputum in rats within 120min increased, and the phase group of saline (P <0.01). Compared with the ammonium chloride group, there was no significant difference between the high dose group and the medium and low dose groups (P <0.01). Conclusion Compound Zhiyuan mixture has antitussive and expectorant effects and is safe.