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目的:探讨周剂量多西紫杉醇联合三维适形放疗(3DCRT)治疗进展期贲门癌患者的疗效。方法:2007年10月到2009年5月38例不能手术的贲门癌患者行3DCRT,处方剂量62Gy,1.8Gy/次,5次/周;同时联合多西紫杉醇75mg/m2,每周1次,连续6周。用Kaplan-Meier法分析患者的中位无进展生存时间。结果:完全缓解12例,部分缓解18例,30名患者缓解(78.9%),中位无进展生存时间16.4个月。治疗过程中的毒副作用轻,患者可以耐受。结论:周剂量多西紫杉醇化疗联合适形放疗对进展期贲门癌患者是安全、有效的。
Objective: To investigate the effect of weekly dose of docetaxel combined with three-dimensional conformal radiotherapy (3DCRT) in the treatment of advanced cardia cancer. METHODS: From October 2007 to May 2009, 38 patients with inoperable cardia cancer underwent 3DCRT at a dose of 62 Gy, 1.8 Gy / time and 5 times / week. Docetaxel was administered simultaneously with 75 mg / m2 once a week, For 6 weeks. The patient’s median progression-free survival time was analyzed by Kaplan-Meier method. Results: Complete remission in 12 cases, partial remission in 18 cases, remission in 30 patients (78.9%), median progression-free survival time of 16.4 months. Side effects of the treatment of light, patients can tolerate. Conclusion: Weekly dose of docetaxel combined with conformal radiotherapy is safe and effective for patients with advanced cardia cancer.