论文部分内容阅读
目的了解普米克短期雾化吸入对咳嗽变异性哮喘(CVA)的疗效及其对血清细胞因子的影响。方法观察CVA患儿普米克雾化吸入7d的疗效并测定治疗前后血清白细胞介素4(IL-4)、γ干扰素(IFN-γ)、IgE水平及外周血嗜酸性粒细胞(EOS)计数。结果雾化组完全缓解时间为(3.9±1.2)d,明显短于未雾化组(5.7±1.2)d。3个月内雾化组复发率7.7%,而未雾化组为30.8%。CVA患儿血清IL-4明显增高,而IFN-γ水平无明显变化。经雾化治疗后IL-4明显下降,而未雾化组降低不明显。CVA患儿血清IgE明显高于对照组,外周血EOS计数则无明显变化。雾化组雾化吸入后IgE有所下降,但仍高于对照组,而未雾化组治疗前后无明显变化。结论普米克短期(7d)雾化吸入治疗可加速CVA的缓解,并明显降低3个月内复发率,迅速降低增高的IL-4水平,但其对血清IgE的影响较小。
Objective To investigate the curative effect of Pulmicort inhalation on cough variant asthma (CVA) and its influence on serum cytokines. Methods The therapeutic effect of inhaling Pulmocost for 7 days in CVA children was observed and the levels of serum IL-4, IFN-γ, IgE and EOS were measured before and after treatment . Results The complete remission time of the nebulized group was (3.9 ± 1.2) d, which was significantly shorter than that of the untreated group (5.7 ± 1.2) d. The rate of relapse in the nebulized group was 7.7% in 3 months and 30.8% in the non-nebulized group. The serum level of IL-4 in children with CVA was significantly increased, while the level of IFN-γ had no significant change. After nebulization, IL-4 decreased significantly, while no decrease was not obvious in nebulized group. The serum IgE of children with CVA was significantly higher than that of the control group, while there was no significant change of EOS count in peripheral blood. IgE decreased slightly after aerosol inhalation in the nebulized group, but still higher than that in the control group, but no change in the non-nebulized group before and after treatment. Conclusion Pulmicort inhalation for 7 days can accelerate the remission of CVA and significantly reduce the relapse rate within 3 months and rapidly decrease the increased IL-4 level, but it has little effect on serum IgE.