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目的:探讨急性脑梗死患者血管成功再通前后血清血红素加氧酶-1(HO-1)的水平变化及其与患者临床特征的关联。方法:选择四川省人民医院神经内科自2018年11月至2019年9月收治的29例行血管内机械取栓治疗且血管成功再通[改良脑梗死溶栓(mTICI)分级≥2b级]的急性脑梗死患者为观察组，选择同期收治的怀疑存在头颈动脉狭窄或颅内动脉瘤而行DSA检查且DSA结果排除头颈动脉病变的22例患者为对照组。采用ELISA法检测观察组患者术前及术后第1、3、7天以及对照组患者DSA检查前后血清HO-1水平，并分析观察组患者的血清HO-1水平与其临床特征的关联。结果:(1)与对照组患者DSA检查前相比，观察组患者的术前血清HO-1水平明显升高，同时其术后第7天的血清HO-1水平亦较术前及术后第1天均明显升高，差异均有统计学意义(n P7分患者明显升高，入院时美国国立卫生研究院卒中量表(NIHSS)评分≤12分患者的术前血清HO-1水平较NIHSS评分>12分患者明显降低，差异均有统计学意义(n P0.05)，但mTICI分级3级患者的术后第7天血清HO-1水平较术后第1天明显升高，差异有统计学意义(n P<0.05)。(4)观察组患者中，发生出血转化患者的术后第3、7天血清HO-1水平均较未发生出血转化患者明显升高，差异均有统计学意义(n P<0.05)；且发生出血转化患者的术后第7天血清HO-1水平亦较术后第1天明显升高，差异有统计学意义(n P<0.05)。n 结论:急性脑梗死患者的血清HO-1水平明显较高，且血管成功再通后可进一步升高，其水平与术前早期脑梗死程度及神经功能缺损程度、术后血管再通程度及出血转化发生等均有关联。“,”Objective:To investigate the changes of serum heme oxygenase 1 (HO-1) level and its correlation with clinical characteristics in patients with acute cerebral infarction (ACI) before and after successful recanalization.Methods:Twenty-nine ACI patients accepted mechanical thrombectomy and enjoyed successful vascular recanalization (Thrombolysis in Cerebral Infarction (mTICI) grading≥2B) in our hospital from November 2018 to September 2019 were enrolled as observation group; 22 patients suspected for carotid artery stenosis or cerebral aneurysm underwent DSA (DSA ruled out the intracranial and carotid artery lesions) were chosen as control group. The level of HO-1 was measured by ELISA before and one, three and 7 d after surgery in the observation group, and before and after DSA in the control group. Besides, the correlation of HO-1 expression level with clinical characteristics of patients in the observation group was analyzed.Results:(1) As compared with the control group before DSA, the serum HO-1 level in the observation group before surgery was significantly higher (n P<0.05); and the serum HO-1 level in the observation group 7 d after surgery was significantly higher than that before and one d after surgery (n P7 from the observation group (n P12 from the observation group (n P0.05); but for patients with mTICI grading 3, the serum HO-1 level 7 d after surgery was significantly higher than that one d after surgery (n P<0.05). (4) The serum HO-1 level in patients with hemorrhagic transformation 3 and 7 d after surgery was significantly higher than that in patients without hemorrhagic transformation from the observation group (n P<0.05); the serum HO-1 level in patients with hemorrhagic transformation 7 d after surgery was significantly higher than that one d after surgery (n P<0.05).n Conclusion:The serum HO-1 level is increased in patients with ACI, and it will further increase after successful recanalization; the serum HO-1 level is related with early infarction degree and neurological deficit degree before surgery, recanalization level and hemorrhagic transformation after surgery.