【摘 要】
：
Hepatitis E virus (HEV) infection is a common public health problem in developing countries.However,the current prevalence of HEV and the relationship of HEV genotype between swine and human within high-density pig-farming areas in central China are still
【机 构】
：
College of Life Sciences, Anhui Normal University,Wuhu 421000, China;Anlu Center for Disease Control
论文部分内容阅读
Hepatitis E virus (HEV) infection is a common public health problem in developing countries.However,the current prevalence of HEV and the relationship of HEV genotype between swine and human within high-density pig-farming areas in central China are still inadequately understood.Here,cross-sectional serological and genotypic surveys of HEV among the 1232 general population,273 workers occupationally exposed to swine,and 276 pigs in a high-density pig-breeding area,were undertaken by ELISA and nested RT-PCR methods.Anti-HEV IgG was detected in 26.22％ of general population and 48.35％ of occupational workers.The prevalence of swine serum HEV-Ag was 6.52％.The prevalence of anti-HEV IgG was significantly higher among the workers occupationally exposed to swine than among the general population.An increased HEV seropositivity risk among the general population was associated with either being a peasant or male and was very strongly associated with the increase of age.Among the occupationally exposed group,the prevalence of anti-HEV IgG antibodies increased with age and working years.Among the 30 HEV-IgM-positive people,the infection rates of clerks in the public,peasants,pork retailers,and pig farmers were higher than those of others.A phylogenetic analysis revealed that all the isolates belonged to subgenotype 4d,and four people and four pigs shared 97.04％-100％ sequence homology.This study revealed a high HEV seroprevalence among the general population and workers occupationally exposed to swine in the Anlu City,and supports the notion that swine are a source of human HEV infection.
其他文献
RNA modifications are abundant in eukaryotes,bacteria,and archaea.N6-methyladenosine (m6A),a type of RNA modification mainly found in messenger RNA (mRNA),has significant effects on the metabolism and function of mRNAs.This modification is governed by thr
Based on the announcement of the World Health Organization (WHO) in 2018,the Wuhan pneumonia caused by an unknown etiology should be recognized as the first Disease X.Later,the pathogen was identified to be a novel coronavirus denoted 2019-nCoV,which has
The 2019-nCoV viral infection causes clusters of severe respiratory illness such as an acute respiratory distress syndrome (ARDS) similar to that caused by SARS-CoV (severe acute respiratory syndrome coronavirus) (Huang et al.2020).Both 2019-nCoV and SARS
Recently the developed single guide (sg)RNA-guided clustered regularly interspaced short palindromic repeats/associated protein 9 nuclease (CRISPR/Cas9) technology has opened a new avenue for antiviral therapy.The CRISPR/Cas9 system uniquely allows target
Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV) has a wide host range.Not only has it been found in humans,but also in many wild and domesticated animals.The infection of breeding deer on farms is a particularly worrisome public health con
The family of flaviviruses is one of the most medically important groups of emerging arthropod-borne viruses.Host cell cytoskeletons have been reported to have close contact with flaviviruses during virus entry,intracellular transport,replication,and egre
Porcine reproductive and respiratory syndrome virus (PRRSV) is characterized by its genetic variation and limited cross protection among heterologous strains.Even though several viral structural proteins have been regarded as inducers of neutralizing anti
Banana bunchy top virus (BBTV) poses a serious danger to banana crops worldwide.BBTV-encoded protein B4 is a determinant of pathogenicity.However,the relevant molecular mechanisms underlying its effects remain unknown.In this study,we found that a functio
Mosquitoes are classified into approximately 3500 species and further grouped into 41 genera.Epidemiologically,they are considered to be among the most important disease vectors in the world and they can harbor a wide variety of viruses.Several mosquito v
Coronaviruses are large, enveloped, positive-strand RNA viruses.Several coronaviruses are pathogenic in humans,including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and this novel virus