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目的:探究重症肺炎患者干扰素-γ、白细胞介素-6和肿瘤坏死因子-α含量变化及其临床意义。方法:选取我院收治并确诊为肺炎的患者103例,根据病情不同,将其分为重症肺炎组52例及普通肺炎组51例,同时选取同期参加健康体检人群50例,为对照组。比较三组成员不同时间段干扰素-γ、白细胞介素-6和肿瘤坏死因子-α含量,重症肺炎组患者存活与死亡组上述因子含量情况。结果:入院6 h后,与对照组比较,重症肺炎及普通肺炎组干扰素-γ、白细胞介素-6及肿瘤坏子因子-α含量较高P<0.05,与普通肺炎组比较,重症肺炎组重症肺炎组干扰素-γ、白细胞介素-6及肿瘤坏子因子-α含量较高P<0.05;入院24 h后,与对照组比较,重症肺炎组干扰素-γ、白细胞介素-6及肿瘤坏子因子-α含量较高P<0.05,普通肺炎组与对照组比较无差异P>0.05;重症肺炎死亡组患者干扰素-γ、白细胞介素-6及肿瘤坏子因子-α含量较高P<0.05。结论:干扰素-γ、白细胞介素-6以及肿瘤坏死因子-α参与患者的免疫调节,可间接提示患者的病程发展,可作为判断病情程度的有利依据。
Objective: To investigate the changes of interferon-γ, interleukin-6 and tumor necrosis factor-α in patients with severe pneumonia and their clinical significance. Methods: A total of 103 patients admitted to our hospital and diagnosed as pneumonia were divided into two groups: 52 cases in severe pneumonia group and 51 cases in common pneumonia group. 50 healthy people were selected as the control group in the same period. The levels of interferon-γ, interleukin-6 and tumor necrosis factor-α in the three groups were compared at different time points. The levels of these factors in the survival and death groups of patients with severe pneumonia were compared. Results: Compared with the control group, the levels of interferon-γ, IL-6 and tumor necrosis factor-α in severe pneumonia group and common pneumonia group were significantly higher than those in the control group 6 h after admission The levels of interferon-γ, interleukin-6 and tumor necrosis factor-α in patients with severe pneumonia were significantly higher than those in patients with severe pneumonia (P <0.05). Compared with the control group, the levels of interferon-γ, interleukin- 6 and tumor necrosis factor-α were significantly higher than those in the control group (P <0.05). There was no difference between the common pneumonia group and the control group (P> 0.05). The levels of interferon-γ, interleukin-6 and tumor necrosis factor- Higher content of P <0.05. Conclusion: Interferon-γ, interleukin-6 and tumor necrosis factor-α are involved in the immune regulation of patients, which can indirectly indicate the course of the disease in patients and can be used as a good basis for judging the severity of the disease.