肠粘膜屏障主要包括机械屏障、免疫屏障、生物屏障,三者之间相辅相成,其功能主要在于防止肠道内细菌及内毒素移位。胃肠道功能的正常发挥有赖于肠粘膜屏障稳定,腹泻、肠易激综合征、炎症性肠病以及全身炎症综合征等诸多临床疾病均存在不同程度的肠粘膜屏障损伤。本文就肠粘膜屏障构成体系,肠屏障损伤与胃肠道疾病的关系的研究情况作综述。 Intestinal mucosal barrier include mechanical barriers, immune barrier, biological barrier, the three complement each other, its main function is to prevent intestinal bacterial and endotoxin translocation. Gastrointestinal function depends on the normal play of intestinal mucosal barrier stability, diarrhea, irritable bowel syndrome, inflammatory bowel disease and systemic inflammatory syndrome and many other clinical diseases there are varying degrees of damage to the intestinal mucosal barrier. This article reviews the research status of the structure of the intestinal mucosal barrier, the relationship between intestinal barrier injury and gastrointestinal diseases.