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目的探讨亚洲人群谷胱甘肽巯基转移酶因GSTM1多态性与前列腺癌易感性的关系。方法检索Pubmed、EMBase、CBM、CNKI、VIP、万方数据平台从建库到2013年8月1日的文献,对所纳入的研究,运用RevMan5.2软件进行meta分析,Stata11.0软件进行Egger’s检验和Begg’s检验。结果共纳入1 3篇病例对照研究,累计样本量为3889例,其中前列腺癌病例组1 444例,对照组2 445例。Meta分析结果可见亚洲人群中GSTM1无效基因型与前列腺癌易感性呈显著性正相关(OR=1.42,95%CI=1.10-1.82,P=0.007)。亚组分析提示,印度人群及东亚人群中,GSTM1无效基因型均显示出能显著增加前列腺癌易感性(OR=1.73,95%CI=1.18-2.53,P=0.005)(OR=1.43,95%CI=1.02-2.02,P=0.04)。各文献间未见明显发表偏倚。结论在亚洲人群中GSTM1无效基因型与前列腺癌易感性呈正相关。
Objective To investigate the relationship between glutathione S - transferase (GSTM1) polymorphism and susceptibility to prostate cancer in Asian population. Methods Pubmed, EMBase, CBM, CNKI, VIP and Wanfang data platform were searched from the database to August 1, 2013. The included studies were performed by using RevMan5.2 software for meta-analysis and Stata11.0 software for Egger’s Test and Begg’s test. Results A total of 13 case-control studies were included. The cumulative sample size was 3889 cases, including 1 444 cases of prostate cancer and 2 445 cases of control. Meta-analysis showed that there was a significant positive correlation between the GSTM1 null genotype and the susceptibility to prostate cancer in Asian population (OR = 1.42, 95% CI = 1.10-1.82, P = 0.007). Subgroup analysis suggested that GSTM1 null genotypes in both Indian and East Asian populations were significantly increased in prostate cancer (OR = 1.73, 95% CI = 1.18-2.53, P = 0.005) (OR = 1.43, 95% CI = 1.02-2.02, P = 0.04). There was no obvious publication bias among the various documents. Conclusions The GSTM1 null genotype in Asian population is positively correlated with the susceptibility to prostate cancer.