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采用荧光偏振等技术方法，体外观察ＣｄＣｌ２对大鼠肝微粒体膜流动性，膜脂质过氧化物丙二醛（ＭＤＡ）生成的毒性作用和维生素Ｃ的拮抗作用。结果表明，ＣｄＣｌ２可在较短时间内引起膜流动性的降低和ＭＤＡ的增高；维生素Ｃ处理不能改善ＣｄＣｌ２引起的微粒体膜流动性的降低，但能完全拮抗ＭＤＡ的增高。结果提示，ＣｄＣｌ２的膜毒性包括了对膜脂质双层的直接作用
Fluorescence polarization and other technical methods were used to observe the toxic effects of CdCl2 on the membrane fluidity of liver microsomes, the membrane lipid peroxides malondialdehyde (MDA) and the antagonism of vitamin C in vitro. The results showed that CdCl2 could reduce membrane fluidity and increase MDA in a short period of time. Vitamin C treatment could not improve the reduction of microsomal membrane fluidity induced by CdCl2, but could completely antagonize the increase of MDA. The results suggest that the membrane toxicity of CdCl2 includes a direct effect on membrane lipid bilayers