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阿尔茨海默病（alzheimer’s disease， AD）是目前全球最常见的痴呆症之一，是一种发病隐匿不可逆转的中枢神经退行性疾病。典型病理改变是老年斑、神经原纤维缠结和神经元丢失。大多数患者在临床诊断为AD时，就已处于AD中晚期，此时已无有效的治疗可逆转疾病的转归。因此，对AD进行早期诊断与干预治疗具有十分重要的意义。本文就近年对AD的功能性MR技术进行综述，以了解轻度认知功能障碍（mild cognitive impairment， MCI）进展为AD的种种表现。“,”Alzheimer’ s disease ( AD) is one of the most common dementia in the world .It is a kind of irreversible central neurodegenerative disease which appears insidiously .The typical pathological changes are senile plaques ,nerve fibers and the loss of neurons .When most patients are diagnosed with AD , they have been in the middle of the AD , and no effective treatment can reserve the prognosis of the disease .Therefore,the early diagnosis and treatment of AD have very important significance .In this paper,we reviewed the functional MR techonology of AD in recent years to understand the development of cognitive impairment mild (MCI) to AD.