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目的:探讨多囊卵巢综合征(PCOS)患者在优质冻融胚胎移植(FET)后是否有更高的妊娠丢失率。方法:回顾性分析诊断为PCOS并初次接受体外受精-胚胎移植(IVF-ET)或卵胞质内单精子注射(ICSI)FET的患者,选择移植冻融胚胎中含有卵裂期优质胚胎且生化妊娠阳性的157个周期的临床资料为PCOS组,同期年龄、体质量指数(BMI)、不孕年限与PCOS组匹配的、因单纯输卵管因素接受IVF-ET助孕治疗并生化妊娠阳性的389个FET周期的临床资料为对照组,比较组间的生化妊娠丢失率、早期流产率、晚期流产率、活产率。结果:在接受优质卵裂期FET的PCOS患者妊娠后,生化妊娠丢失率、早期流产率、晚期流产率、活产率与对照组相比(8.28%vs 5.14%、7.64%vs 8.13%、6.94%vs 5.15%、79.86%vs 84.28%),差异无统计学意义(P>0.05)。结论:在固定胚胎质量这个重要的影响妊娠早期丢失的影响因子的基础上,排除年龄、BMI、自然流产次数、是否多胎妊娠、移植日内膜厚度等影响因素的干扰,患PCOS并不增加IVF/ICSI的生化妊娠丢失率和临床妊娠流产率。
OBJECTIVE: To investigate whether there is a higher rate of pregnancy loss in women with polycystic ovary syndrome (PCOS) after high-quality frozen-thawed embryo transfer (FET). Methods: We retrospectively analyzed patients with PCOS diagnosed with IVF-ET or ICSI FET and selected embryos with high-quality cleavage stage and biochemical pregnancy Positive 157 cycles of clinical data for the PCOS group, the same age, body mass index (BMI), infertility and PCOS group matched due to simple tubal factor IVF-ET assisted pregnancy and biochemical pregnancy-positive 389 FET The clinical data of the cycle were control group. The rate of biochemical pregnancy loss, early miscarriage rate, late miscarriage rate and live birth rate were compared between groups. Results: The rate of biochemical pregnancy loss, early miscarriage rate, late miscarriage rate, and live birth rate in PCOS patients receiving high-quality cleavage-phase FETs were significantly lower than those in the control group (8.28% vs. 5.14%, 7.64% vs 8.13%, 6.94 % vs 5.15%, 79.86% vs 84.28%), the difference was not statistically significant (P> 0.05). Conclusion: Based on the influence of fixed embryo quality, which is an important influencing factor of early pregnancy loss, excluding the influence factors such as age, BMI, number of spontaneous abortion, multiple pregnancy and endometrial thickness on transplantation day, PCOS did not increase IVF / ICSI biochemical pregnancy loss rate and clinical pregnancy abortion rate.