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利用壳多糖缓慢降解的特性，把它与阿霉素制成壳多糖阿霉素缓释药粒，植入家兔胫骨上端进行体内释放试验，并与静注相同剂量阿霉素的家兔进行比较。结果表明，该缓释药可使阿霉素在局部骨组织中维持较高浓度达８周以上，且骨组织中最高浓度是静注相同剂量阿霉素时骨含量的２９倍，但血浆峰值浓度仅为静注组血浆峰值的１／１３。因此，壳多糖与阿霉素制成的缓释药粒具有良好的缓释功能，该缓释药粒阿霉素的一次局部用量可超过静注一次用量的１０余倍，能较好地满足骨肿瘤局部化疗用药量大、维持时间长、血液浓度低、全身反应小的用药要求。
Using the characteristics of slow degradation of chitin, it was made into adriamycin with chitosan doxorubicin sustained-release granules and implanted in the upper humerus of rabbits for in vivo release test, and was performed with rabbits intravenously injected with doxorubicin at the same dose. Compare. The results showed that the sustained-release drug can maintain a high concentration of doxorubicin in the local bone tissue for more than 8 weeks, and the highest bone tissue concentration is 29 times the bone content of intravenous doxorubicin at the same dose, but the plasma peak The concentration is only 1/13 of the plasma peak in the intravenous group. Therefore, the sustained-release drug particles made of chitin and doxorubicin have a good sustained-release function, and the local dosage of the sustained-release drug doxorubicin can exceed 10 times of the intravenous injection amount, and can be well satisfied. Local chemotherapy for bone tumors requires large doses of chemotherapy, long duration of maintenance, low blood levels, and low systemic response.